Efficacy Of The Autoimmune Protocol Diet As Part Of A Multi-disciplinary, Supported Lifestyle Intervention For Hashimoto's Thyroiditis

Effect Decrease
Values The reduction in hs-CRP was also significant after removal of two outliers (1.22 mg/L, SD 0.81 pre to 0.85 mg/L, SD 0.72 post; P = 0.037), but levels remained within the average risk range.
Trial Design Non-controlled trial
Trial Length 1-6 months
Number of Subjects 17
Sex Female
Age Range 18-29, 30-44, 45-64
Body Types Overweight, Average
Notes for this study:
In this open-label, uncontrolled pilot study, 17 women aged 20-45 with a prior diagnosis of Hashimoto’s thyroiditis (HT) and a mean (SD) BMI of 24.9 (2.6) participated in a 10-week online health coaching program on the implementation of the AIP.

Before and after the program, quality of life and clinical symptom burden were measured with the 36-Item Short Form Health Survey (SF-36) and the Cleveland Clinic Center for Functional Medicine's Medical Symptoms Questionnaire (MSQ). Blood was also collected for complete blood count, complete metabolic profile, thyroid function, thyroid antibodies, and high-sensitivity C-reactive protein (hs-CRP).

There were significant improvements in quality of life and symptom burden scores. The reduction in hs-CRP was also significant, but levels remained within the average risk range. After removing one outlier, the reduction in white blood cell count was also significant, though this mean was also within normal range. Mean weight and BMI were also significantly lower after the program. There were no changes in measures of thyroid function or thyroid antibodies. Six of the 13 women that had been using thyroid replacement medication reduced their dosages after the program.
Funding issues for this study:
The study authors received $11,428.60 as part of a community crowdfunding campaign to cover some study expenses. Genova Diagnostics provided testing supplies including 40 comprehensive stool analysis tests and 40 nutritional organic acid tests. Financial relationships: One author declared personal fees from Autoimmune Wellness LLC; he is a medical advisor for the health and wellness initiative Autoimmune Wellness LLC. He receives $2000 yearly for his participation with this entity. Another author is co-founder of Autoimmune Wellness LLC, and her group online health coaching program was used as the primary intervention for this study.