Studies related to Ammonia and Glutamine

The Safety Of Oral Use Of L-glutamine In Middle-aged And Elderly Individuals

Effect None
Trial Design Double blind
Trial Length 1-2 Weeks
Number of Subjects 30
Gender Both Genders
Age Range 65+
Body Types Average
Notes for this study:
Increases in creatinine and urea (not ammonia) were seen after oral administration of 0.5g/kg glutamine in elderly persons (69+/-8.8 years); these changes were not deemed to be clinically relevant, although they were statistically.

The glomerular filtration rate decreased 13.3%, but was considered to be below the biologically significant 25% marker. The authors thought that other biomarkers noted (increase in urea and creatinine) were due to inefficient renal excretion.

Glutamine Protects Against Increases In Blood Ammonia In Football Players In An Exercise Intensity-dependent Way

Effect Both
Trial Design Double blind
Trial Length 1-7 Days
Number of Subjects 30
Gender Male
Age Range 18-29
Body Types Trained, Overweight
Notes for this study:
In a sample of professional football (American) players, 100mg/kg bodyweight glutamine supplementation was able to reduce serum increases in ammonia in response to exercise when taken chronically (5 days); it appeared to raise it acutely (single dose). Supplemental Alanine did similar effects as glutamine.

Urate was increased 10-20% acutely, with no influence over 5 days; Urea was increased 10-20% acutely and remained 10% elevated after 5 days. Creatinine release during exercise (biomarker of muscle damage) was unaffected by supplementation.

Glutamine And Carbohydrate Supplements Reduce Ammonemia Increase During Endurance Field Exercise

Effect Decrease
Trial Design Double blind
Trial Length 1-7 Days
Number of Subjects 15
Gender Male
Age Range 18-29, 30-44
Body Types Trained, Average
Notes for this study:
Ammonia levels in endurance exercise were significantly decreased with oral glutamine supplementation at 70mg/kg ingestion _only_ after the first hour of activity, with no differences in the first hour.