| Effect | Increase |
| Trial Design | Cohort |
| Trial Length | 1-6 months |
| Number of Subjects | 67 |
| Gender | Female |
| Age Range | 18-29, 30-44 |
| Body Types | Average |
Supplementation of a vitex agnus castus supplement (Prefemin; 20mg of a 60% water-ethanolic extract; 6-12:1 concentrated) daily for three menstrual cycles in an open-label study noted that all symptoms of PMS decreased when measured at the first and third cycles compared to baseline.Funding issues for this study:
Medication appears to be well tolerated aside from one acute reaction which appeared to be allergic dermatitis.
Some potential conflicts of interest with authors and the manufacturer of the supplement