Studies related to Sleep Quality and Vitex agnus-castus

Efficacy And Safety Of Vitex Agnus-castus Extract For Treatment Of Premenstrual Syndrome In Japanese Patients: A Prospective, Open-label Study

Supplementation of a vitex agnus castus supplement (Prefemin; 20mg of a 60% water-ethanolic extract; 6-12:1 concentrated) daily for three menstrual cycles in an open-label study noted that all symptoms of PMS decreased when measured at the first and third cycles compared to baseline.

Medication appears to be well tolerated aside from one acute reaction which appeared to be allergic dermatitis.

Some potential conflicts of interest with authors and the manufacturer of the supplement