Studies related to Irritability and Vitex agnus castus

Therapeutic Effect Of Vitex Agnus Castus In Patients With Premenstrual Syndrome

Effect Decrease
Trial Design Double blind
Trial Length 6+ Months
Number of Subjects 128
Gender Female
Age Range 18-29, 30-44
Body Types Overweight, Average
Notes for this study:
4.5mg (40 drops) of Vitex Agnus taken 6 days prior to menstruation and continued for 3 months was associated with improved symptoms of PMS relative to placebo.

Efficacy And Safety Of Vitex Agnus-castus Extract For Treatment Of Premenstrual Syndrome In Japanese Patients: A Prospective, Open-label Study

Effect Decrease
Trial Design Cohort
Trial Length 1-6 months
Number of Subjects 67
Gender Female
Age Range 18-29, 30-44
Body Types Average
Notes for this study:
Supplementation of a vitex agnus castus supplement (Prefemin; 20mg of a 60% water-ethanolic extract; 6-12:1 concentrated) daily for three menstrual cycles in an open-label study noted that all symptoms of PMS decreased when measured at the first and third cycles compared to baseline.

Medication appears to be well tolerated aside from one acute reaction which appeared to be allergic dermatitis.
Funding issues for this study:
Some potential conflicts of interest with authors and the manufacturer of the supplement