Studies related to Intestinal Motility and Senna alexandrina

Standardized Senna In The Management Of Constipation In The Puerperium: A Clinical Trial

Effect Increase
Trial Design Double blind
Trial Length 24 hours
Number of Subjects 471
Gender Female
Age Range 18-29, 30-44
Body Types Overweight, Average
Notes for this study:
It was found that Senna was more effective than placebo in reducing constipation and increasing intestinal motility in persons tested, with minimal side-effects of cramping, at 14mg Sennosides A+B in the morning and evening.

The Use Of Senna With Docusate For Postoperative Constipation After Pelvic Reconstructive Surgery: A Randomized, Double-blind, Placebo-controlled Trial

Effect Increase
Trial Design Double blind
Trial Length 1-7 Days
Number of Subjects 48
Gender Both Genders
Notes for this study:
93 patients, after pelvic surgery, were randomized to either placebo or 8.6mg senna (paired with docusate at 50mg). Experimental group had a significantly reduced time to bowel evacuation compared to placebo.

Safety And Efficacy Of A Bulk Laxative Containing Senna Versus Lactulose In The Treatment Of Chronic Constipation In Geriatric Patients

Effect Increase
Trial Design Cohort
Trial Length 24 hours
Number of Subjects 30
Gender Both Genders
Age Range 65+
Body Types Average
Notes for this study:
Senna was compared to lactulose in regards to treating constipation in a group of geriatric patients, and was found to be of equal efficacy yet more financially desirable (and more financially 'efficient')

Comparative Study Of Two Bowel Preparation Regimens For Colonoscopy: Senna Tablets Vs Sodium Phosphate Solution

Effect Increase
Trial Design Cohort
Trial Length 24 hours
Number of Subjects 134
Gender Both Genders
Age Range 45-64
Body Types Average
Notes for this study:
180mg senna, compared to 95mL sodium phosphate solution, was less effective than sodium phosphate in cleaning the bowels yet was associated with less side-effects and a better reported compliance (assessed by taste)

Efficacy Of Senna Versus Lactulose In Terminal Cancer Patients Treated With Opioids

Effect Increase
Trial Design Cohort
Trial Length 1-7 Days
Number of Subjects 91
Gender Both Genders
Age Range 45-64, 65+
Notes for this study:
Senna root was compared to lactulose for its usage as a laxative in cancer patients, and no significant differences were found in regards to their efficacy and side-effects; Senna was recommended on the basis of economy.

Comparison Of The Effect Of Drugs Upon Some Commonly Used Measures Of Bowel Transit Time

Effect Increase
Trial Design Double blind
Trial Length 24 hours
Number of Subjects 8
Gender Male
Age Range 18-29, 30-44
Body Types Average
Notes for this study:
Senna was found to be more effective than placebo in inducing dumping and increasing bowel transit time, and interestingly was shown to negate the slowing effects of adrenaline on bowel time.

A Volunteer Model For The Comparison Of Laxatives In Opioid-related Constipation

Effect Increase
Trial Design Double blind
Trial Length 24 hours
Number of Subjects 23
Gender Both Genders
Age Range 18-29, 30-44
Body Types Average
Notes for this study:
Senna was able to significantly reduce opioid-induced constipation, but was associated with more side-effects (abdominal pain) relative to placebo.

Senna Vs Polyethylene Glycol For Mechanical Preparation The Evening Before Elective Colonic Or Rectal Resection: A Multicenter Controlled Trial. French Association For Surgical Research

Effect Increase
Trial Design Cohort
Trial Length 24 hours
Number of Subjects 523
Gender Both Genders
Age Range 30-44, 45-64, 65+
Body Types Average
Notes for this study:
In a multi-center single-blind analysis of Senna root against PEG for usage prior to surgery in bowel cleansing, it was found that Senna was more effective than PEG in regards to overall bowel cleansing while no significant differences exited between groups for side-effects.

The Bowel Cleansing For Colonoscopy. A Randomized Trial Comparing Three Methods

Effect Increase
Trial Design Cohort
Trial Length 24 hours
Number of Subjects 273
Gender Both Genders
Age Range 30-44, 45-64
Notes for this study:
Senna (paired with magnesium citrate) at 12mg (MgCt at 15mg) capsules were compared against PEG solution (2L) with bisacodyl as well as against sodium phosphate at 40mL.

Sodium phophate appeared most effective of the three laxative tests, with senna coming in second place.

Half Doses Of PEG-ES And Senna Vs. High-dose Senna For Bowel Cleansing Before Colonoscopy: A Randomized, Investigator-blinded Trial

Effect Increase
Trial Design Cohort
Trial Length 24 hours
Number of Subjects 296
Gender Both Genders
Notes for this study:
In comparing a half dose Senna group (12mg) paired with 2 liters of Polyethylene Glycol (PEG) against a high dose Senna group (24mg), both groups experienced a good degree of bowel cleansing but the high dose Senna group experienced more reports of moderate to severe abdominal pain (15.2% relative to 6%)