Studies related to Bone Mineral Density and Soy Protein

Animal Versus Plant Protein And Adult Bone Health: A Systematic Review And Meta-Analysis From The National Osteoporosis Foundation

Effect None
Values %Change (95% CI). Lumbar spine: 0.24 (-0.80, 1.28). Femoral neck: 0.13 (-.94, 1.21). Total body: -0.24 (-0.81, 0.33)
Trial Design Meta analysis
Trial Length n/a
Number of Subjects 0
Sex n/a
Notes for this study:
The study was a meta-analysis of studies that investigated the effects on bone health of the same intake of animal compared with plant protein. The studies were all in healthy participants besides osteopenia/osteoporosis, and hypertension in some of those who were 45 years old or older. Children and adolescents were excluded, as well as pregnant or lactating women.

Across 4 randomized, controlled trials comparing isoflavone-rich soy protein with animal protein of various kinds, there wasn't a significant or notable difference in lumbar spine bone mineral density, which received a C for Strength Of Evidence. Across 3 studies, the effect was the same for femoral neck BMD and total body BMD, which received a D and C, respectively. Total hip bone mineral density wasn't significantly different in two studies. Total body bone mineral content wasn't significantly different in the 3 studies that evaluated it. There were also no significant differences for bone-specific alkaline phosphatase and other biomarkers of bone health, and there was insufficient evidence to evaluate the risk of falls, and fractures. There weren't significant differences for bone mineral density of the lumbar spine, femoral neck, or for bone-specific alkaline phosphatase when comparing isoflavone-poor soy protein to animal protein, but this was based on only two studies.
Funding issues for this study:
"Funding for this study was provided through unrestricted educational grants from Dairy Management, Inc., Egg Nutrition Center and the Beef Checkoff. The funders provided support in the form of graduate student stipends for authors MSW, ZF, MK, JoS, and JiS, but did not have any additional role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. Only TW was knowledgeable of the original funding sources until the manuscript was submitted for publication. Disclaimer: MC, KI, ML, SS and CW contributed their efforts without receiving funding or salary support."