| Effect | Increase |
| Trial Design | Double blind |
| Trial Length | 2-4 Weeks |
| Number of Subjects | 40 |
| Sex | Male |
| Age Range | 18-29 |
| Body Types | Trained, Average |
28 days supplementation of 2,500-5,000mg Reishi (water soluble polysaccharides) in football players subject to high altitude sleeping conditions (training at sea level) noted that only the higher dose was able to stimulate CD3+ T-cells above control levels while both attenuated the changes in the CD4:CD8 ratio (training reduced CD4 relative to CD8, and reishi attenuated this change).
