Studies related to Oxidation of LDL and Ketogenic diet

Comparison Of A Very Low-carbohydrate And Low-fat Diet On Fasting Lipids, LDL Subclasses, Insulin Resistance, And Postprandial Lipemic Responses In Overweight Women

Effect None
Values Oxidized LDL. (mU/L). Mean + SD. Baseline: 6.9 ± 1.8 Ketogenic: 6.8 ± 1.2 Low fat: 6.9 ± 2.2
Trial Design Randomized trial
Trial Length 2-4 Weeks
Number of Subjects 13
Sex Female
Body Types Overweight
Notes for this study:
In a randomized, unblinded crossover trial, 13 healthy, overweight participants were assigned to a ketogenic diet with <10% carbohydrate, 30% protein, and 60% fat or a low fat diet with 55% carbohydrate, 20% fat and 25% protein for 4 weeks for each condition. Diets were designed to be isocaloric and hypocaloric, though participants received education on the diets and had to prepare them by themselves. Self-reporting suggested that the participants on the ketogenic diet were on average eating <10%, and calorie intake was low, suggesting a ketogenic carbohydrate intake. Participants also tested themselves for urinary ketones, but the results of this testing were not shared.

After the diets, the ketogenic diet condition led to higher total cholesterol, LDL, and HDL, all of which were statistically significant between groups. The ketogenic diet reduced triglycerides more than the low fat group, but the difference wasn't statistically significant. There was no apparent effect on oxidized LDL. Blood glucose, insulin, and HOMA-IR (insulin resistance) were lower on the ketogenic diet, and the differences were statistically significant between groups. There was a shift towards larger LDL on the ketogenic diet.
Funding issues for this study:
"This study was supported by a grant from The Robert C. Atkins Foundation, New York, NY."

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