Metabolic Impact Of A Ketogenic Diet Compared To A Hypocaloric Diet In Obese Children And Adolescents
Notes for this study:
||(mmol/L). Mean + SD. Keto: before 8.64 ± 1.43, after 10.92 ± 2.35. Control: before 10.1 ± 1.25, after 9.31 ± 1.21.
|Number of Subjects
In a randomized, unblinded trial, 58 obese children were assigned to a ketogenic diet or a hypocaloric diet with the goal to lose at least 10% of their body weight for 6 months. The ketogenic diet was to contain <20 g of carbohydrates per day with a gradual increase to 30/40, with no restrictions on caloric intake. The hypocaloric diet was to be about 28-33% fat and 50-55% carbohydrate and was designed to reduce calories by 500 below maintenance daily. Participants were educated on the diets and their guardians were to adhere to them. Adherence was measured through urinary ketone testing. 38 participants completed all 6 months.
The ketogenic diet group saw a statistically significant reduction in weight, fat mass, waist circumference, fasting insulin, and insulin resistance, and an increase in adiponectin compared with baseline, while the hypocaloric group saw less weight loss, fat loss, reduction in weight circumference, improvement in insulin resistance, and less adiponectin. Other outcomes can be found in the values boxes in their respective HEM entries.