The Effects Of Carbohydrate Variation In Isocaloric Diets On Glycogenolysis And Gluconeogenesis In Healthy Men
Notes for this study:
||(nmol/L). Mean + SE. Ketogenic: 0.24 ± 0.05 Medium carb: 0.31 ± 0.05 High carb: 0.31 ± 0.07
|Number of Subjects
||18-29, 30-44, 45-64
In a randomized crossover study, 6 healthy participants were assigned to one of 3 isocaloric liquid diets for 11 days each: a high carbohydrate diet with 15% of calories as protein and 85% carbohydrate, 15% protein, 44% carbohydrate and 41% fat, or 15% protein, 2% carbohydrate, and the rest fat.
Fasting glucose, insulin, and c-peptide were statistically significantly reduced on the ketogenic diet compared with the other two diets. Glucagon, cortisol, epinephrine, and norepinephrine were not significantly different, though a modest increase in cortisol and reduction in epinephrine was noted on the ketogenic diet. The ketogenic diet group saw more gluconeogenesis and less glycogenolysis than the other groups.