Low-fat Versus Ketogenic Diet In Parkinson's Disease: A Pilot Randomized Controlled Trial

Effect Both
Values MDS‐UPDRS. Mean + SD. Part 1 (nonmotor daily living experiences. Ketogenic: before 11.15  ± 4.15, after 6.57  ± 4.09. Control: before 8.96  ± 4.34, after 7.96  ± 6.56. Part 2 (motor daily living experiences): Ketogenic: before 12.75  ± 5.30, after 9.62  ± 5.64. Control: before 11.13  ± 5.59, after 9.80  ± 6.81. Part 3 (motor examination): before 36.48  ± 13.29, after 30.20  ± 12.88. Control: before 34.93  ± 13.40, after 26.36  ± 13.58. Part 4 (motor complications): Ketogenic: before 4.90  ± 3.95, after 3.33  ± 3.02 Control: before 4.33  ± 4.44, after 3.54  ± 4.86.
Trial Design Randomized trial
Trial Length 1-6 months
Number of Subjects 47
Sex Both Genders
Body Types Obese, Overweight, Average, Underweight
Notes for this study:
In a randomized, unblinded pilot trial, 47 Parkinson's disease patients were assigned to a ketogenic diet containing 152 g of fat, 75 g protein, and 16 g carbohydrate or an isocaloric diet containing 42 g of fat, 75 g of protein, and 246 g of carbohydrate for 8 weeks.

The primary outcome was the score on the MDS-UPDRS parts 1 to 4 after 8 weeks. The ketogenic diet group saw a greater improvement in nonmotor daily living experiences, motor daily living experiences, and motor complications, though only the first was statistically significant. The control group saw a slightly greater improvement in the motor examination, which was almost statistically significant (0.055.

The ketogenic group saw a statistically significant greater increase in HDL, LDL, total cholesterol, and urate compared with the control group, and a nonsignificant increase in c-reactive protein and a decrease in HbA1c. Neither group differed notably in weight loss and triglycerides.

Examination of adverse effects generally suggested less hunger on the ketogenic diet, more irritability and tremors initially, but which returned to similar levels as the control group after 4 weeks. Nausea was also a side-effect of the ketogenic diet, particularly in the first 4 months, after which it was less notable (13% vs. 0% for ketogenic and control).

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