Improvements In Vascular Health By A Low-fat Diet, But Not A High-fat Diet, Are Mediated By Changes In Adipocyte Biology
Notes for this study:
||Figure 3 in paper.
|Number of Subjects
In a randomized, unblinded trial, 17 healthy, obese participants were assigned to a high fat ketogenic or low-fat diet for 6 weeks. All food and beverages were provided by the researchers and the diets were designed to be hypocaloric and isocaloric.
The low-fat diet notably improved flow-mediated dilation while the ketogenic diet worsened it, with the difference being statistically significant. Adiponectin was significantly higher on the low-fat diet while the ketogenic diet didn't see a change, leptin was reduced more on the low-fat diet, and resistin was also lower on the low-fat diet.
There was a small reduction in body weight in the ketogenic group compared with the low-fat group, but the low-fat group lost more fat mass and less fat-free mass than the ketogenic group, though the difference wasn't statistically significant. Systolic blood pressure improved more on the low-fat diet, while there were no other statistically significant results for other outcomes (data in the "values" boxes of their respective HEM entries).