Effects Of Weight Loss From A Very-low-carbohydrate Diet On Endothelial Function And Markers Of Cardiovascular Disease Risk In Subjects With Abdominal Obesity
Notes for this study:
||Augmentation Index (%). Mean + SD. Ketogenic: before 29.4± 9.6, after 28.9 ± 10.2. Control: before 28.1 ± 12.8, after 27.6 ± 9.4
|Number of Subjects
In a randomized, unblinded controlled trial, 107 healthy obese participants were assigned to a ketogenic diet with 35% protein, 61% fat, and 4% carbohydrate or an isocaloric high carbohydrate diet with 24% protein, 30% fat, and 46% carbohydrate for 8 weeks. The diets were designed to be 30% calories less than needed for weight loss. Participants were educated about the diet, and adherence was measured via plasma ketones.
The ketogenic group lost more weight and slightly more fat mass and fat-free mass, though only weight was statistically significant between groups. There was no statistically significant difference between groups for fasting glucose and insulin. There was a significantly significant greater increase in HDL and decrease in triglycerides in the ketogenic diet group. The control group saw a greater reduction LDL and c-reactive protein, and a significantly greater increase in homocysteine and folate. Other outcomes can be found in the "values" box of their respective HEM entries.