Effects Of Weight Loss From A Very-low-carbohydrate Diet On Endothelial Function And Markers Of Cardiovascular Disease Risk In Subjects With Abdominal Obesity

Effect None
Values (ng/mL). Mean + SD. Ketogenic: before 455 ± 86, after 375 ± 72. Control: before 467 ± 122, after 410 ± 96.
Trial Design Randomized trial
Trial Length n/a
Number of Subjects 107
Sex Both Genders
Body Types Obese
Notes for this study:
In a randomized, unblinded controlled trial, 107 healthy obese participants were assigned to a ketogenic diet with 35% protein, 61% fat, and 4% carbohydrate or an isocaloric high carbohydrate diet with 24% protein, 30% fat, and 46% carbohydrate for 8 weeks. The diets were designed to be 30% calories less than needed for weight loss. Participants were educated about the diet, and adherence was measured via plasma ketones.

The ketogenic group lost more weight and slightly more fat mass and fat-free mass, though only weight was statistically significant between groups. There was no statistically significant difference between groups for fasting glucose and insulin. There was a significantly significant greater increase in HDL and decrease in triglycerides in the ketogenic diet group. The control group saw a greater reduction LDL and c-reactive protein, and a significantly greater increase in homocysteine and folate. Other outcomes can be found in the "values" box of their respective HEM entries.