Lack Of Suppression Of Circulating Free Fatty Acids And Hypercholesterolemia During Weight Loss On A High-fat, Low-carbohydrate Diet

Effect None
Values Log-transformed mean + SD. (mg/dl). Fasting: Keto: −2.7 ± 3.1 High carb: −1.9 ± 3.3. 24-hour: Ketogenic: −59.7 ± 70.8 High carb: 50.2 ± 54.8
Trial Design Randomized trial
Trial Length 1-6 months
Number of Subjects 32
Sex n/a
Age Range 18-29, 30-44, 45-64, 65+
Body Types Obese
Notes for this study:
In a randomized, unblinded trial, 32 healthy obese participants were assigned to a ketogenic diet or low-fat diet for 6 weeks. The ketogenic diet was designed to contain less than 20 g of carbs per day and the high carb diet was less than 30% fat, 15% protein, and 55% carbohydrate. Participants were educated about the diets and ketone testing was used to measure adherence.

Both groups lost the same amount of weight. The ketogenic diet group saw a greater increase in LDL which was statistically significant compared with the high carbohydrate group. There were no other statistically significant differences on fasting tests, including HDL, free fatty acds, glucose, insulin, triglycerides, and remnant lipoprotein cholesterol, however free fatty acids increased considerably more in the ketogenic group, and triglycerides and insulin declined more.

When the researchers took measures over 24 hours of feeding, there was a statistically significant increases in free fatty acids and a significant decrease in glucose and insulin in the ketogenic group. There was no different in remnant lipoprotein cholesterol, and the ketogenic group had lower triglyceride levels, but this wasn't statistically significant.