Benefit Of Low-fat Over Low-carbohydrate Diet On Endothelial Health In Obesity
Notes for this study:
||Maximum FMD, %. Mean + SE. Ketogenic: before 8.2±0.7, after 6.8±0.6. Low fat: before 6.8±0.7, after 8.7±0.9. Baseline diameter, (mm). Ketogenic: before 3.42±0.21, after 3.58±0.23. Low fat: before 3.94±0.25, after 3.85±0.28. Peak diameter (mm). Ketogenic: before 3.77±0.24, after 3.82±0.24. Low fat: before 4.29±0.30, after 4.26±0.27. Baseline peak velocity (cm/s). Ketogenic: before 60.8±5.9, after 65.7±3.2. Low fat: before 54.0±3.0, after 53±3.7. Baseline mean velocity, (cm/s). Ketogenic: before 36.2±3.7, after 38.5±2.5. Low fat: before 32.3±1.7, after 31.5±2.0. Reactive hyperemia peak velocity (cm/s). Ketogenic: before 105.2±10, after 116.9±6.3. Low fat: before 104±7.0, after 115.1 ±7.0. Reactive hyperemia mean velocity (cm/s). Ketogenic: before 58.6±6.0, after 67.7±3.2. Low fat: before 59.4±6.15, after 61.4±3.5. Peak change in flow velocity (%). Ketogenic: before 76.0±12, after 80.0±8.0. Low fat: before 83.8±9, after 101 ±10. Maximum nitroglycerin dilation (%). Ketogenic: before 20.9±0.02, after 20.6±0.02. Low fat: before 21.30±0.023, after 19.30±0.02
|Number of Subjects
In a randomized, single-blind trial, 20 healthy, obese participants were assigned to either a ketogenic diet containing 20 g of carbohydrate per day or a low fat diet containing 30% of calories as fat for 6 weeks Both diets were designed to provide participants 750 calories fewer than maintenance and all food was provided.
Flow-mediated dilation was the primary outcome. After 2 weeks there was a slight, nonsignificant reduction in flow-mediated dilation in the ketogenic group compared with the low fat group, and after 6 weeks there was a greater, statistically significant reduction in the low carbohydrate great and a large, statistically significant increase in the low fat group. There was no statistically significant difference for other measures of arterial function.
There were no statistically significant differences betweengroups for other measures taken, including BMI, weight, lean body mass, total cholesterol, LDL, HDL, triglycerides, blood pressure, insulin, glucose, and c-reactive protein, however the ketogenic diet group saw a greater increase in LDL, less reducttion in HDL, and a greater reduction in insulin and triglycerides,