Ketogenic Low-carbohydrate Diets Have No Metabolic Advantage Over Nonketogenic Low-carbohydrate Diets
Notes for this study:
||Plasma (mmol/L). Ketogenic: before 0.36 ± 0.04, after 0.32 ± 0.04. Normal carb: before 0.37 ± 0.04, after 0.34 ± 0.03
|Number of Subjects
||18-29, 30-44, 45-64
In a randomized, controlled trial, 20 overweight/obese participants were assigned to either a ketogenic diet with 5% carbohydrate initially which increased by 5 g per week during the second half of the trial, or an isocaloric diet with the same amount of protein and with 40% carbohydrates for 6 weeks. All food was provided to the participants and the diets were hypocaloric and designed to lead to weight loss. Following the 6 weeks, there was also a period of 4 weeks where participants self-monitored their diets.
Funding issues for this study:
There wasn't a statistically significant difference between groups when it came to weight loss after 6 weeks, and the difference wasn't statistically significant during the following weeks, though the higher carb group lost a little more weight. The change in resting energy expenditure wasn't notably different. There was a similar improvement in insulin sensitivity in both groups and c-reactive protein was reduced more in the ketogenic group, but the ketogenic group started off with considerably higher levels.
Other outcomes can be found in the "values" boxes of the individual HEM entries.
"SLT received consulting fees from the Inflammation
Research Foundation for participation in the research presented here. HH is
an employee of Zone Labs Inc. BS is a stockholder and serves on the boards
of directors of Zone Labs Inc and Zone Cuisine Inc; he is also on the boards
of directors of Zone Café and ZoneNet."