Carbohydrate Restriction With Postmeal Walking Effectively Mitigates Postprandial Hyperglycemia And Improves Endothelial Function In Type 2 Diabetes

Effect Decrease
Values Figure 3.
Trial Design Randomized trial
Trial Length 1-7 Days
Number of Subjects 11
Sex Both Genders
Age Range 45-64, 65+
Body Types Overweight, Average
Notes for this study:
This paper contains additional data from another entry. In a randomized crossover trial, 16 overweight/obese participants with type 2 diabetes were assigned to either a ketogenic diet with less than 10% carbohydrate, 25% protein, and the rest fat, or an isocaloric low-fat, low-glycemic index diet with 55% of calories as carbohydrate, 20% as fat, and 25% as protein for 4 days each, with 9-14 days washout between conditions. All food was provided.

5 participants dropped out, leaving 11 for analysis. There was no notable effect of the ketogenic diet on flow-mediated dilation, but it worsened in the high carbohydrate group, the difference being statisticaqlly significant. The ketogenic diet group say an increase in c-reactive protein while the high carbohydrate group saw no change, but the difference wasn't statistically significant. There was also a significant reduction in endothelial microparticles in the ketogenic group. Other vascular outcomes can be found in the "values" boxes in their respective HEM entries.