Benefit Of Low-fat Over Low-carbohydrate Diet On Endothelial Health In Obesity
Notes for this study:
||(mg/dl). Mean + SD. Ketogenic diet: before 82.4±14.2, after 95.4±13.7. Low fat diet: before 93.8±6.8, after 84.4±9.2
|Number of Subjects
In a randomized, single-blind trial, 20 healthy, obese participants were assigned to either a ketogenic diet containing 20 g of carbohydrate per day or a low fat diet containing 30% of calories as fat for 6 weeks Both diets were designed to provide participants 750 calories fewer than maintenance and all food was provided.
Flow-mediated dilation was the primary outcome. After 2 weeks there was a slight, nonsignificant reduction in flow-mediated dilation in the ketogenic group compared with the low fat group, and after 6 weeks there was a greater, statistically significant reduction in the low carbohydrate great and a large, statistically significant increase in the low fat group. There was no statistically significant difference for other measures of arterial function.
There were no statistically significant differences betweengroups for other measures taken, including BMI, weight, lean body mass, total cholesterol, LDL, HDL, triglycerides, blood pressure, insulin, glucose, and c-reactive protein, however the ketogenic diet group saw a greater increase in LDL, less reducttion in HDL, and a greater reduction in insulin and triglycerides,