Lipolysis And Gluconeogenesis From Glycerol During Weight Reduction With Very-low-calorie Diets
Notes for this study:
||(nmol/L). Ketogenic: before 1.7 ± 0.1, after 0.8 ± 0.1. Nonketogenic: before 1.9 ± 0.2, after 1.2 ± 0.1
|Number of Subjects
In a randomized, controlled trial, 20 obese participants were assigned to a 615 calorie ketogenic diet containing 70 g of protein, 33 g of fat, and 9 g of carbohydrate per day or an isocaloric diet containing 70 g of protein, 3 g of fat, and 86 g of carbohydrate for 28 days.
The ketogenic group lost slightly more weight (0.9 kg on average) but the difference wasn't statistically significant and it was within the range that could be explained by water weight. There were no statistically significant differences between groups for the for change in metabolic outcomes such as free fatty acids, glucose, insulin, glucagon, or thyroid hormones, though the ketogenic group saw a greater reduction in fasting glucose and a greater increase in free fatty acids, while the nonketogenic group say a greater increase in glucagon. Other outcomes can be seen in the "values" boxes of their respective HEM entries.