Supplementation With Vitamin D Or ω-3 Fatty Acids In Adolescent Girls And Young Women With Endometriosis (SAGE): A Double-blind, Randomized, Placebo-controlled Trial

Effect Decrease
Values Pain scores decreased by average of 0.7/10, which was actually less than placebo decrease.
Trial Design Randomized trial
Trial Length 1-6 months
Number of Subjects 69
Sex n/a
Age Range 13-17, 18-29
Notes for this study:
In this registered clinical trial, 69 young women with surgically confirmed endometriosis and endometriosis-associated pelvic pain (EAPP) took either vitamin D3 (2000 IU), fish oil (1g), or placebo (lactose powder) daily for 6 months, starting about 6 weeks after surgery. All the patients reported an improvement in pelvic pain. The vitamin D and placebo (lactose) groups had similar reductions in pelvic pain, with no statistically significant difference between them, but the fish oil group actually had less improvement than lactose placebo.
Funding issues for this study:
Supported by a New England Fertility Society/Ferring REI Fellow research grant (to JLN); a Department of Obstetrics, Gynecology, and Reproductive Biology, Brigham and Women's Hospital, Expanding the Boundaries research grant (to JLN); a McCarthy Family Foundation research grant (to ADD); the J Willard and Alice S Marriott Foundation (to SAM); NIH research grants HD48544 and HD52473 from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (to SAM); Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI) grant CA50385 (to SAM); and NCI grant K22 CA193860 (to HRH).