Studies related to Intestinal Permeability and Fish oil

The Impact Of Probiotics And N-3 Long-chain Polyunsaturated Fatty Acids On Intestinal Permeability In Pregnancy: A Randomised Clinical Trial

Effect None
Values Mean change in placebo+placebo from early to late gestation: Serum zonulin (ng/mL): 4.0 (95% CI: 0.8-7.2) Serum LPS (EU/mL): 0.04 (95% CI: 0.027-0.054) Mean change in fish oil + placebo from early to late gestation: Serum zonulin (ng/mL): 5.2 (95% CI: 2.0-8.5) Serum LPS (EU/mL): 0.03 (95% CI: 0.018-0.041) P-value between all four groups by one-way ANOVA Serum zonulin: 0.8 Serum LPS: 0.2
Trial Design Randomized trial
Trial Length 1-6 months
Number of Subjects 200
Sex Female
Age Range 18-29, 30-44
Body Types Overweight
Notes for this study:
200 women in early gestation (mean: 14 weeks) were randomized to one of four groups: placebo, fish oil, probiotic, or both fish oil and probiotic until late gestation (mean: 35 weeks). The fish oil dose was 2.4 grams daily containing 79.6% DHA and 9.7% EPA. The probiotic contained 10^10 CFU of _Bifidobacterium animalis_ ssp. _lactis_ 420 and _Lactobacillus rhamnosus_ HN001. The study’s primary outcome was to test effects on intestinal permeability by measuring the difference in serum zonulin and serum LPS between early and late pregnancy. There was no significant effect on these metrics for fish oil, probiotic, or their combination.
Funding issues for this study: