Studies related to Cognition and Fish oil

Effect Of Long-term Omega 3 Polyunsaturated Fatty Acid Supplementation With Or Without Multidomain Intervention On Cognitive Function In Elderly Adults With Memory Complaints (MAPT): A Randomised, Placebo-controlled Trial

Effect None
Values All metrics are changes in composite Z-scores of four cognitive tests compared to the control group. Multidomain plus PUFA: 0.093 (95% CI: 0.001-0.184) Multidomain plus placebo: 0.075 (95%CI: 0.090-0.179) PUFA alone: 0.011 (95% CI: -0.081 to 0.103)
Trial Design Randomized trial
Trial Length 6+ Months
Number of Subjects 1525
Sex Both Genders
Age Range 65+
Notes for this study:
People over 70 with memory complaints but without dementia were assigned to one of four groups: 800 mg DHA + 225 mg EPA daily with or without a multidomain intervention, the multidomain intervention plus placebo, or a control group. The multidomain intervention consisted of group sessions focusing on mental stimulation, physical activity and nutrition along with yearly doctor consultations with a focus on managing function and cardiovascular disease risk factors.

The primary outcome was a composite Z-score combining the results of four cognitive tests: free and total recall from the Free and Cued Selective Reminding Test, ten items related to orientation from the Mini-Mental State Exam, and the Digit Symbol Substitution Test from the Wechsler Adult Intelligence Scale—Revised, and the Category Naming Test.

After adjustment for multiple comparisons, none of the three treatment conditions was statistically significantly different from the control group. Before adjustments, the multidomain-plus-omega-3 group had a borderline statistically significant effect(p=0.047) with a very small effect size (Z= 0.093).
Funding issues for this study: