Studies related to Migraine Frequency and Fish oil

The Synergistic Effects Of ω-3 Fatty Acids And Nano-curcumin Supplementation On Tumor Necrosis Factor (TNF)-α Gene Expression And Serum Level In Migraine Patients

Effect Decrease
Values Episodes per week ± SEM: Placebo: −0.53 ± 0.32; Nano-curcumin: −0.98 ± 0.33; Fish oil: −1.10 ± 0.33; Combination: −2.09 ± 0.34
Trial Design Randomized trial
Trial Length 1-6 months
Number of Subjects 38
Sex Both Genders
Age Range 30-44
Body Types Overweight, Average
Notes for this study:
This was a four-arm trial involving placebo, fish oil, nano-curcumin, or the latter two’s combination for two months. The study’s goal was to explore the effects of these supplements on people with episodic migraine as well as to explore possible mechanisms of the supplements’ putative effectiveness.

Reporting issues make the results a bit unclear. However, it seems like both fish oil and nano-curcumin supplementation resulted in roughly one less migraine attack per week, and their combination resulted in two fewer weekly attacks. Supplementation also reduced TNF-alpha gene expression in peripheral blood mononuclear cells and TNF-alpha serum levels to a borderline statistically significant extent, with the combination of nano-curcumin and fish oil outperforming the individual supplements.
Funding issues for this study: