Effect Of Eicosapentaenoic Acid And Docosahexaenoic Acid Supplementation On C-peptide Preservation In Pregnant Women With Type-1 Diabetes: Randomized Placebo Controlled Clinical Trial
Notes for this study:
||Change between 1st and 3rd trimesters (mean±SD) in pmol/L: Control: 10.2±56.6 Fish oil: 35.0±104.3 P = 0.17
|Number of Subjects
The main goal of this study was to explore whether fish oil supplementation could help preserve pancreatic function and glycemic control in pregnant women with type 1 diabetes. Ninety pregnant women with type 1 diabetes were put on a standard diabetic diet and randomized to receive either 120 mg EPA + 616 mg DHA from 9th week of gestation or corn oil placebo from the 9th week of gestation through birth. There was no clear impact of supplementation on maternal fasting C-peptide level or HbA1c; both metrics improved equally in both groups over the course of the study. Interestingly, C-peptide in the umbilical vein was lower in the treatment group, which was unexpected. The authors speculate on several reasons why this may have happened.
Funding issues for this study: