Studies related to Thermic effect of food (TEF) and Vegan Diet

Effect Of A Low-Fat Vegan Diet On Body Weight, Insulin Sensitivity, Postprandial Metabolism, And Intramyocellular And Hepatocellular Lipid Levels In Overweight Adults: A Randomized Clinical Trial

Effect Increase
Values Thermic effect of food increased in the intervention group by 14.1% (95% CI, 6.5-20.4; P < .001) compared to baseline after 16 weeks of eating a low-fat vegan diet.
Trial Design Randomized trial
Trial Length 1-6 months
Number of Subjects 244
Sex Both Genders
Age Range 18-29, 30-44, 45-64, 65+
Body Types Obese, Overweight
Notes for this study:
In this 16-week randomized controlled trial, 244 obese participants were told to either follow a low-fat vegan diet or make no diet changes. The researchers then assessed the changes in body weight, insulin resistance, postprandial metabolism, and lipid levels after 12 weeks compared to baseline and between the groups.

After 16 weeks, the vegan diet group lost 5.9 kg of body weight and showed improved insulin sensitivity, as shown by a HOMA-IR decrease of -1.3. Hepatocellular lipid levels decreased by 34% while intramyocellular lipids (meaning, the lipids stored in fat droplets of muscle cells) were reduced by 10%. Also, the thermic effect of food was increased by 14% in the vegan diet group. In contrast, none of these variables changed significantly in the control group over the 16 weeks.

Overall, a low-fat vegan diet reduced body weight and lipid levels and improved insulin sensitivity and the thermic effect of food in overweight and obese adults compared to no dietary changes in a control group.
Funding issues for this study:
Conflict of Interest Disclosures: Dr Kahleova reported being director of clinical research at the Physicians Committee, a nonprofit organization that provides nutrition education and research. Dr Rembert reported compensation from the Physicians Committee for Responsible Medicine outside the submitted work. Dr Holubkov reported receiving personal fees from the Physicians Committee for Responsible Medicine during the conduct of the study. Dr Barnard reported to serving as president of the Physicians Committee for Responsible Medicine and Barnard Medical Center; receiving royalties from Hachette Book Group, Penguin Random House, Rodale, and Da Capo publishers; and receiving honoraria from Yale, Rush, George Washington, Loma Linda, Rockford Universities, Montefiore Medical Center, the Mayo Clinic, Northwell Health, Christiana Care, Oticon, and the National Organization of Professional Athletes. No other disclosures were reported.

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