Studies related to Total Cholesterol and Berberine

Berberine In The Treatment Of Type 2 Diabetes Mellitus: A Systemic Review And Meta-analysis

Effect Decrease
Trial Design Meta analysis
Trial Length n/a
Number of Subjects 1068
Gender n/a
Notes for this study:
In diabetic patients, Berberine at 0.5-1.5g daily for an average period of 12 weeks was associated with minor to moderate improvements on all measured glucose and lipid parameters; rivalling oral hypoglycemics in potency

Treatment Of Type 2 Diabetes And Dyslipidemia With The Natural Plant Alkaloid Berberine

Effect Decrease
Trial Design Double blind
Trial Length 1-6 months
Number of Subjects 116
Gender Both Genders
Age Range 18-29, 30-44, 45-64
Body Types Overweight
Notes for this study:
Berberine in isolation at 1g for 3 months was able to reduce triglycerides and fasting glucose levels in type II diabetics. Total cholesterol and LDL also decreased, and an increase in glucose disposal rate was seen.

Insulin sensitivity showed a trend for improvement, but did not reach statistical significance.

Efficacy Of Berberine In Patients With Non-Alcoholic Fatty Liver Disease

Effect Decrease
Values -0.52mmol/L for lifestyle changes plus berberine versus -0.12mmol/L for lifestyle alone.
Trial Design Randomized trial
Trial Length 1-6 months
Number of Subjects 184
Gender Both Genders
Age Range 30-44, 45-64, 65+
Body Types Obese, Overweight
Notes for this study:
184 patients with nonalcoholic fatty liver disease were randomized to one of three arms for 16 weeks: lifestyle intervention alone, lifestyle interventions plus 15mg pioglitazone daily, or lifestyle interventions plus 0.5g berberine three times a day. Berberine plus lifestyle changes significantly improved liver fat content, BMI, HOMA-IR, total cholesterol, and triglycerides significantly more than lifestyle interventions alone. The berberine group tended to have minor digestive issues that tended to resolve 2 weeks into the study.

Effects Of Berberine On Lipid Profile In Subjects With Low Cardiovascular Risk

Effect Decrease
Values Dropped from 214mg/dL to 191mg/dL on average, and was significantly different from placebo
Trial Design Randomized trial
Trial Length 6+ Months
Number of Subjects 144
Gender Both Genders
Age Range 30-44, 45-64, 65+
Body Types Overweight, Average
Notes for this study:
This was a challenge/rechallenge trial. After a 6 month lifestyle intervention run-in period consisting of diet and exercise, 144 Caucasian patients with high cholesterol but with otherwise overall low cardiovascular risk were given even 500mg berberine twice a day or placebo for 3 months and anthropometric measurements were taken along with lipid panels and liver function tests. Berberine/placebo treatment was then ceased for 2 months and the measurements retaken. Berberine or placebo was then reintroduced for another 3 months and the measurements taken one final time. Berberine decreased total cholesterol, triglycerides, and LDL-C while raising HDL-c compared to placebo.