Studies related to C-Reactive Protein and Rose Hip

Rose Hip Inhibits Chemotaxis And Chemiluminescence Of Human Peripheral Blood Neutrophils In Vitro And Reduces Certain Inflammatory Parameters In Vivo

Effect Decrease
Trial Design Cohort
Trial Length 1-6 months
Number of Subjects 13
Gender Both Genders
Age Range 30-44, 45-64
Body Types Average
Notes for this study:
Rose hip supplementation at 10g (low dose) or 45g (high dose) in otherwise healthy persons appeared to reduce C-reactive protein by 20-40% at the higher dose and also reduced creatinine concentrations. There was no observed effect on other parameters measured aside from chemotaxis, which was reduced by over 50% in 12/13 persons.

Effects Of Rose Hip Intake On Risk Markers Of Type 2 Diabetes And Cardiovascular Disease: A Randomized, Double-blind, Cross-over Investigation In Obese Persons

Effect None
Trial Design Double blind
Trial Length 1-6 months
Number of Subjects 31
Gender Both Genders
Age Range 30-44, 45-64
Body Types Obese
Notes for this study:
Supplemenation of a high dose (40g) of rosehip powder via a beverage daily for six weeks in obese persons without diabetes was able to reduce blood pressure mildly (3.7%) with minor reductions in total cholesterol due to the LDL component, although no other measured biomarker was changed.

The Anti-inflammatory Properties Of Rose-hip

Effect Decrease
Trial Design Cohort
Trial Length 1-6 months
Number of Subjects 8
Gender Male
Age Range 18-29, 30-44
Notes for this study:
Supplementation of either 10g or 45g rose hip powder extract to otherwise healthy men for one month was able to reduce C-reactive protein concentrations (up to 30-35%) and reduced chemotaxis of polymorphonuclear leukocytes by up to 50% (low dose) and 65% (high dose). It was also noted in four of the persons characterized by high physical work (due to their occupation) that rosehip alleviated joint discomfort.

All changes returned to baseline values after cessation of rosehip supplementation.

The Effects Of Rose Hip (Rosa Canina) On Plasma Antioxidative Activity And C-reactive Protein In Patients With Rheumatoid Arthritis And Normal Controls: A Prospective Cohort Study

Effect None
Trial Design Cohort
Trial Length 1-6 months
Number of Subjects 30
Gender Female
Age Range 45-64
Body Types Average
Notes for this study:
Supplementation of 10.5g rose hip powder daily for four weeks in persons with rheumatoid arthritis as well as a group of healthy controls failed to reduce symptoms of rheumatoid arthritis or to influence biomarkers (red blood cell antioxidant enzymes or C-reactive protein) relative to baseline; no placebo group was used in this study.

Rose Hip Herbal Remedy In Patients With Rheumatoid Arthritis - A Randomised Controlled Trial

Effect Decrease
Trial Design Double blind
Trial Length 1-6 months
Number of Subjects 89
Gender Both Genders
Age Range 45-64, 65+
Body Types Average
Notes for this study:
Rose hip supplementation at 5g for six months in persons with rheumatoid arthritis appeared to show benefits on a health assessment questionnaire (HAQ) at six months yet not three. While there was a trend to improve overall symptoms of rheumatism by clinician rating and DAS-28 rating, the rating scale selectively looking at pain in joints (HAQ patient pain scale) failed to find any benefit. C-reactive protein trended to decrease but failed to reach statistical significance.

Degree of improvement on the global symptoms reached 30% (physician rating) and 19% (DAF-28) relative to baseline values.