Studies related to Anxiety and Caffeine

Association Of The Anxiogenic And Alerting Effects Of Caffeine With ADORA2A And ADORA1 Polymorphisms And Habitual Level Of Caffeine Consumption

Effect Increase
Trial Design Double blind
Trial Length n/a
Number of Subjects 400
Sex n/a
Notes for this study:
Anxiety, as assessed by self-report surveys, was significantly higher than placebo in persons with a single-nucleotide polymorphism (TT) of the adenosine A2A receptor after consuming two small (100,150mg) doses of caffeine.

Evidence for a genetic connection between anxiety and caffeine.

Also increased anxiety in persons unaccustomed to caffeine intake on a daily basis independent of genotype.