Association Of The Anxiogenic And Alerting Effects Of Caffeine With ADORA2A And ADORA1 Polymorphisms And Habitual Level Of Caffeine Consumption
Notes for this study:
|Number of Subjects
Anxiety, as assessed by self-report surveys, was significantly higher than placebo in persons with a single-nucleotide polymorphism (TT) of the adenosine A2A receptor after consuming two small (100,150mg) doses of caffeine.
Evidence for a genetic connection between anxiety and caffeine.
Also increased anxiety in persons unaccustomed to caffeine intake on a daily basis independent of genotype.