| Effect | Decrease |
| Trial Design | Double blind |
| Trial Length | 1-6 months |
| Number of Subjects | 151 |
| Sex | Female |
| Age Range | 30-44, 45-64 |
| Body Types | Obese |
16 weeks of using Xanthigen (300mg Pomegranate seed oil + 300mg seaweed extract giving 2.4mg fucoxanthin daily) was able to reduce bodyweight in obese non-diabetic females independent of the state of the liver, and decreased waist circumference only in the group with fatty liver, which was most likely secondary to reducing liver fat and liver enzymes in the group with NAFLD. All other parameters were seen in both the fatty liver groups as well as non-fatty liver groups (differentiation done at 11% liver fat)
Fucoxanthin also demonstrated a dose-dependent increasing of metabolic rate (REE) up to 8mg (highest tested), from 5.95kJ/min to 7.37kJ/min, the higher end of the scale correlating to an increase of 1915 ± 246 kJ/24 h relative to baseline. These differences only manifested after 16 weeks (were not acute), 1.6mg fucoxanthin daily was not deemed clinically effective (minimum dose 2.4mg established for significance)
