| Effect | Increase |
| Trial Design | Double blind |
| Trial Length | 24 hours |
| Number of Subjects | 35 |
| Gender | Both Genders |
| Age Range | 18-29 |
Oral ingestion of 2.1g D-serine in otherwise healthy adult subjects two hours prior to cognitive testing (CPT-IP for sustained attention, BVRT, and RAVLT) in a double-blind crossover study found that supplementation reduced testing anxiety and sadness (no influence on reaction time) alongside the main parameter of increased working memory (word retention and immediate recall).Funding issues for this study:
Other tests involved backwards recall (not superior to placebo) and forward (benefits of D-serine over placebo) with an improvement in the Category Fluency test. On the BVRT, D-serine was significantly better than baseline values but due to a nonsignificant increase in placebo there was no difference between groups.
Potential conflict of interest with intellectual property rights of D-serine in movement disorders and schizophrenia