Studies related to Verbal Fluency and D-Serine

Behavioral And Cognitive Effects Of The N-methyl-D-aspartate Receptor Co-agonist D-serine In Healthy Humans: Initial Findings

Effect None
Trial Design Double blind
Trial Length 24 hours
Number of Subjects 35
Gender Both Genders
Age Range 18-29
Notes for this study:
Oral ingestion of 2.1g D-serine in otherwise healthy adult subjects two hours prior to cognitive testing (CPT-IP for sustained attention, BVRT, and RAVLT) in a double-blind crossover study found that supplementation reduced testing anxiety and sadness (no influence on reaction time) alongside the main parameter of increased working memory (word retention and immediate recall).

Other tests involved backwards recall (not superior to placebo) and forward (benefits of D-serine over placebo) with an improvement in the Category Fluency test. On the BVRT, D-serine was significantly better than baseline values but due to a nonsignificant increase in placebo there was no difference between groups.
Funding issues for this study:
Potential conflict of interest with intellectual property rights of D-serine in movement disorders and schizophrenia