Studies related to Anxiety and Sceletium tortuosum

Acute Effects Of Sceletium Tortuosum (Zembrin), A Dual 5-HT Reuptake And PDE4 Inhibitor, In The Human Amygdala And Its Connection To The Hypothalamus

Effect Decrease
Trial Design Double blind
Trial Length 24 hours
Number of Subjects 15
Sex Both Genders
Age Range 18-29
Notes for this study:
In otherwise healthy young adults, oral administration of 25mg of an extract (2:1 concentration) prior to a perceptual load task failed to find a significant reduction in errors (reaction time) when compared to placebo.

When assessing the emotional response to the task there appeared to be less amygdala activity in response to a high cognitive load, and as assessed by fMRI there was greater amygdalic activity with supplementation relative to placebo during testing.