Creatine Supplementation In Fibromyalgia: A Randomized, Double-blind, Placebo-controlled Trial
| Effect | Increase |
| Values | When compared to the placebo group, the creatine group had a statistically significant increase in chest press strength when compared to placebo group. Delta chest press strength. Creatine group: +1.2% Placebo group: 7.2%. Mean SD difference between delta changes 3.4 ± 1.0 [95% CI —5.5, —1.3]; P = 0.002 |
| Trial Design | Randomized trial |
| Trial Length | 1-6 months |
| Number of Subjects | 32 |
| Sex | n/a |
| Age Range | 30-44, 45-64, 65+ |
| Body Types | Overweight, Average |
This randomized controlled trial had the subjects consume either creatine monohydrate or a placebo for 16-weeks. The participants in the creatine arm began taking 20 grams for 5 days divided into 4 equal doses, which was then followed by consuming 5 grams daily for the rest of the intervention. The placebo group was given the same protocol but consumed dextrose. Muscle function, aerobic conditioning, cognition, quality of sleep, kidney function and muscle phosphorylcreatine content was measured before and after the study.
There were improvements in leg and chest press strength and increased intramuscular phosphocreatine content. However, there were no statistically significant improvements in symptoms of fibromyalgia and quality of life.
