Creatine Supplementation In Fibromyalgia: A Randomized, Double-blind, Placebo-controlled Trial
Notes for this study:
||When compared to the placebo group, the creatine group showed a statistically significant increase in leg press strength by the end of the 16-week intervention. Delta change in leg press strength in kilograms. Creatine group +9.8% Creatine: — 0.5%. Mean ± SD difference between delta changes —5.1 ± 2.2 [95% CI —9.6, —0.6]; P = 0.02
|Number of Subjects
||30-44, 45-64, 65+
This randomized controlled trial had the subjects consume either creatine monohydrate or a placebo for 16-weeks. The participants in the creatine arm began taking 20 grams for 5 days divided into 4 equal doses, which was then followed by consuming 5 grams daily for the rest of the intervention. The placebo group was given the same protocol but consumed dextrose. Muscle function, aerobic conditioning, cognition, quality of sleep, kidney function and muscle phosphorylcreatine content was measured before and after the study.
There were improvements in leg and chest press strength and increased intramuscular phosphocreatine content. However, there were no statistically significant improvements in symptoms of fibromyalgia and quality of life.