Supplementation With Creatine Monohydrate In Children With Mitochondrial Encephalomyopathies

Effect Decrease
Trial Design Cohort
Trial Length 1-6 months
Number of Subjects 4
Sex Both Genders
Age Range 7-12, 13-17
Notes for this study:
In children with mitochondrial encephalomyopathy (n=4), an unblinded series of controlled case studies found that 100-200 mg/kg/day for at least 3 months improved both physical endurance (30-57% in three patients) and power output (8-17%) relative to baseline. An increase in daily function and quality of life was also reported. These benefits declined to baseline values when creatine supplementation was stopped.

The myopathies in this study were MELAS (n=1), KSS (n=2), and NARP (n=1).

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