Studies related to Malondialdehyde (MDA) and Vitamins E and C

Effect Of Vitamins C And E Supplementation On Peripheral Oxidative Stress Markers And Pregnancy Rate In Women With Endometriosis

Effect Decrease
Values Plasma levels reduced from 28 umol/L at baseline to 17 at 4mo and 12 at 6 mo
Trial Design Randomized trial
Trial Length 1-6 months
Number of Subjects 34
Sex Female
Age Range 18-29, 30-44
Notes for this study:
34 women with infertility & peritoneal endometriosis took either placebo (16 women) or Vit. C + E (18 women, C 343 mg, E 84 mg) daily for 6 months, while taking no other hormonal treatments.

The participants' plasma at months 0, 2, 4, and 6 was sampled and analysed for malondialdehyde (MDA) and lipid hydroperoxides (LOOHs), which are biomarkers of oxidative stress. The plasma levels of these biomarkers was reduced significantly in the vitamin group, to significantly lower levels than the placebo group's.

The participants were also followed for pregnancy during the trial and for 9 months afterwards. The pregnancy rate wasn't statistically significant between the two groups.
Funding issues for this study:
This work was supported by Grant SALUD-2002-C-01-7615/A- 1 from the Consejo Nacional de Ciencia y Tecnología, Mexico.