Studies related to Endothelin-1 and Spirulina

Spirulina Maxima Decreases Endothelial Damage And Oxidative Stress Indicators In Patients With Systemic Arterial Hypertension: Results From Exploratory Controlled Clinical Trial

Effect Decrease
Values pg/ml. Mean and SD. Placebo: before 17.45 ± 6.11, after 21.48 ± 2.17. Spirulina: before 14.42 ± 2.92 after 11.90 ± 6.47.
Trial Design Randomized trial
Trial Length 1-6 months
Number of Subjects 16
Sex Both Genders
Notes for this study:
In a 12-week randomized, single-blind pilot trial, 16 participants with systemic arterial hypertension who were taking ACE inhibitors took 4.5 g of spirulina maxima or placebo daily.

Blood pressure was reduced more in the spirulina group. There were also improvements in sVCAM-1, sE-Selectin, Endothelin-1 but not sICAM-1. There were also general improvements in antioxidant status, though not oxidative stress.