Protective Effects Of Haematococcus Astaxanthin On Oxidative Stress In Healthy Smokers

Effect Increase
Values TAC. Figure 3B.
Trial Design Randomized trial
Trial Length 2-4 Weeks
Number of Subjects 39
Sex Both Genders
Notes for this study:
In a randomized, non-placebo-controlled trial with unclear blinding, 39 heavy smokers were allocated to take 5, 20, or 40 mg of astaxanthin daily for 3 weeks.

Malondialdehyde was considerably reduced after 3 weeks in all groups, with the greatest reduction in the 40 mg group, though the differences between groups weren't statistically significant. Free isoprostane was also considerably reduced, almost to 0, and there were no notable differences between groups after 3 weeks. Total antioxidant capacity of plasma and superoxide dismutase were increased similarly in all groups except the 20 mg group saw a greater increase than the others for superoxide dismutase.

When all groups were considered together, there was a statistically significant reduction in blood glucose, increase in phosphorus, increase in alkaline phosphate, increase in white blood cells, increase in carbon dioxide, increase in platelets, and increase in erythrocyte sedimentation rate.

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