Studies related to Leukocyte Count and Echinacea

A Proprietary Extract From The Echinacea Plant (Echinacea Purpurea) Enhances Systemic Immune Response During A Common Cold

Effect Increase
Values Mean and SEM. 10⁹ /L. Placebo: before 5.8 ± 0.2, 2 days 6.1 ± 0.3, 7 days 5.7 ± 0.2. Echinacea: before 5.7 ± 0.2, 2 days 6.7 ± 0.4, 7 days 6.6 ± 0.5
Trial Design Randomized trial
Trial Length 1-7 Days
Number of Subjects 62
Sex Both Genders
Age Range 18-29, 30-44, 45-64, 65+
Notes for this study:
In a randomized, double-blind, placebo-controlled trial, 150 participants who were prone to colds were recruited, and 62 developed a cold and were given 8 doses of 5 ml of a 40% ethanol echinacea extract containing alkamides/cichoric acid/polysaccharides at concentrations of 0.25/2.5/25.5 mg/mL, respectively on the first dose and 3 on each of the next 6 days, or placebo.

Total daily symptoms were lower when taking echinacea than placebo, and the difference was statistically significant after the third day. There was also an increase in total leukocytes, monocytes, and neutrophils, but not lymphocytes, and the respiratory burst capacity of neutrophils, while there was a decrease in erythrocyte superoxide dismutase units during echinacea.
Funding issues for this study:
Contract/grant sponsor: Factors R & D Technologies, Burnaby, BC,
Canada.