Concentrated Red Grape Juice Exerts Antioxidant, Hypolipidemic, And Antiinflammatory Effects In Both Hemodialysis Patients And Healthy Subjects

Effect None
Values (ug/L). Mean + SEM. Before 447 (47), after 426 (47)
Trial Design Randomized trial
Trial Length 2-4 Weeks
Number of Subjects 61
Sex Both Genders
Notes for this study:
In a randomized 36 patients with stable angina who had been receiving maintenance hemodialysis and 15 healthy controls were allocated to take 50 ml of a red grape juice concentrate (total polyphenols, 0.64 g/100 mL) twice per day or control (no intervention) for 2 weeks. The healthy participants all received the supplement. In another study, 10 hemodialysis patients were given the red grape juice supplement for 3 weeks.

There were no statistically significant or notable differences between groups for the change in glucose, uric acid, serum protein, or albumin after 2 weeks. There were no significant changes for triglycerides, but total and LDL cholesterol were reduced, HDL was increased, apo-A was increased, and apo B was decreased significantly more in both juice grapes than the control group.

The uncontrolled study of healthy participants consuming the juice found reductions in MCP-1 but not CRP, C3, ICAM-1 or VCAM-1.