Two Concentrations Of Topical Tretinoin (retinoic Acid) Cause Similar Improvement Of Photoaging But Different Degrees Of Irritation. A Double-blind, Vehicle-controlled Comparison Of 0.1% And 0.025% Tretinoin Creams
|Trial Design||Double blind|
|Trial Length||6+ Months|
|Number of Subjects||98|
|Age Range||45-64, 65+|
Topical administration of two creams containing retinol (0.1% and 0.025%) over the course of 48 weeks improved signs of photoaging including mottled hyperpigmentation, fine wrinkles, and brown spots (actinic lentigines) with no differences in potency between groups while the lower concentration was associated with occurrence rates (scaling and erythema) of 44% in the 0.1% group and only 13% in the 0.025% group.