Studies related to Wrinkles and Vitamin A

Topical Tretinoin Improves Photoaged Skin. A Double-blind Vehicle-controlled Study

Effect Decrease
Trial Design Double blind
Trial Length 1-6 months
Number of Subjects 30
Sex Both Genders
Age Range 45-64
Notes for this study:
In persons with photoaged skin (35-70 years) given an 0.1% retinol cream nightly for 16 weeks improved skin quality relative to placebo cream in all subjects mostly by a reduction in fine wrinkling, but also with benefits in pinkess, coarse wrinkling, and tactile roughness.

During biopsy, forearm skin from the vitamin A treated arm appeared to be 273% thicker relative to baseline whereas placebo only saw an 18% increase.

3/40 subjects withdrew due to vitamin A related dermatitis, while most subjects had some degree of mild dermatitis associated with vitamin A not leading to discontinuation.

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