Studies related to Collagen Content and Vitamin A

Improvement Of Naturally Aged Skin With Vitamin A (retinol)

Effect Increase
Trial Design Double blind
Trial Length 1-6 months
Number of Subjects 33
Sex Both Genders
Age Range 65+
Notes for this study:
Application of a cream containing 0.4% retinol three times a week for 24 weeks in elderly subjects was able to increase procollagen I expression and glycosaminoglycan expression in skin, and resulted in a significantly less wrinkled appearance compared to placebo lotion.

Tactile roughness was also reduced.

Side-effects were fairly common after 24 weeks (redness, itching, dryness, burning sensations) but were mostly quite mild in severity, not commonly causing dropouts.