Studies related to C-Reactive Protein (CRP) and Saffron

The Effects Of Saffron (Crocus Sativus L.) On Mental Health Parameters And C-reactive Protein: A Meta-analysis Of Randomized Clinical Trials

Effect Decrease
Values WMD: -0.71; 95% CI: -1.66, 0.23
Trial Design Meta analysis
Trial Length n/a
Number of Subjects 0
Sex n/a
Notes for this study:
This was a meta-analysis of randomized, controlled trials that evaluated the effects of saffron on mental health parameters and/or c-reactive protein. Overall, 21 trials were included, ranging from 4 to 12 weeks and with doses of 22 to 1,00 mg/day. There were 563 participants in intervention groups and 489 in control groups.

There was an improvement in depression according to the Beck Depression Inventory-II, and in anxiety according to the Beck Anxiety Inventory. The effect based on the Hamilton Depression Rating Scale (HDRS-D), and Hamilton Anxiety Rating Scale were not statistically significant. Pittsburgh Sleep Quality Index saw a statistically significant improvement. The reduction in CRP wasn't statistically significant.

There was evidence of publication bias via Egger's test for HDRS-D, BDI, and PSQI but not the others.

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