Studies related to Sleep Disturbances and Saffron

Effects Of Saffron On Sleep Quality In Healthy Adults With Self-reported Poor Sleep: A Randomized, Double-blind, Placebo-controlled Trial

Effect Decrease
Values # of awakenings. Mean and SE. Placebo: before 3.15 (0.27), after 2.98 (0.25). Saffron: before 3.23 (0.27), after 2.51 ( 0.25)
Trial Design Randomized trial
Trial Length 1-6 months
Number of Subjects 63
Sex Both Genders
Age Range 18-29, 30-44, 45-64, 65+
Notes for this study:
In a 28-day randomized, double-blind, placebo-controlled trial, 63 healthy participants took 28 mg of saffron extract (Crocus sativus L. and standardized to contain more than 3.5% Lepticrosalides) or placebo daily.

The primary outcome was insomnia severity according to the Insomnia Severity index, and there was a greater improvement in the saffron group. There wasn't a difference in the change in total sleep time or sleep latency, while the number of awakenings was lower and overall subjective sleep quality was higher. There wasn't a difference in mood open awaking, but alertness was improved, and participants reported more restorative sleep subjectively.

Adverse events weren't notably different.

The trial was preregistered: ACTRN12619000863134
Funding issues for this study:
"The authors gratefully acknowledge Pharmactive Biotech Products SL for funding
the project and supplying affron and LIPA Pharmaceuticals for the preparation of
the tablets"