Studies related to Thyroid-Stimulating Hormone and Saffron

Safety Evaluation Of Saffron Stigma (Crocus Sativus L.) Aqueous Extract And Crocin In Patients With Schizophrenia

Effect Increase
Values Mean and SD. Placebo: before 1.1±0.6, after 1.0±0.5. Crocin, before 1.3±0.8, after 1.6±1.0. Saffron: before 1.8±1.6, after 2.2±2.4.
Trial Design Randomized trial
Trial Length 1-6 months
Number of Subjects 66
Sex Both Genders
Age Range 18-29, 30-44, 45-64
Notes for this study:
In a randomized, double-blind, placebo-controlled trial, 66 participants with schizophrenia took 30 mg of saffron aqueous extract or crocin daily, or placebo, for 12 weeks.

The saffron group saw an increase in white blood cell count, but not red blood cells, hemoglobin, hematocrit, or platelets. There weren't statistically significant differences for liver enzymes, urea, creatinine, erythrocyte sedimentation rate, c-reactive protein, T3, T4, or TSH, though TSH increased in the saffron group.

The trial was preregistered: IRCT2013020312351N1