| Effect | Decrease |
| Values | Hamilton Depression Rating Scale. Saffron: before 21.12 (2.35), after 9.92 (4.51). Sertraline: before 21.40 (2.86), after 8.76 (4.52) |
| Trial Design | Randomized trial |
| Trial Length | 1-6 months |
| Number of Subjects | 50 |
| Sex | Both Genders |
| Age Range | 45-64, 65+ |
In a randomized, double-blind, placebo-controlled trial, 50 participants over the age of 60 took 60 mg of saffron or 100 mg of sertraline daily for 6 weeks.
Both groups saw a similar reduction in depression.
The trial was preregistered: IRCT20120215009014N204
