Studies related to Fibromyalgia and Saffron

Saffron ( Crocus Sativus) Versus Duloxetine For Treatment Of Patients With Fibromyalgia: A Randomized Double-blind Clinical Trial

Effect Decrease
Values FIQ. Mean and SD. Duloxetine: before 54.25 (11.87), after 41.35 (10.48). Saffron: before 52.65 (13.34), after 42.13 (10.75).
Trial Design Randomized trial
Trial Length 1-6 months
Number of Subjects 54
Sex Both Genders
Age Range 18-29, 30-44, 45-64
Notes for this study:
In a randomized, double-blind, placebo-controlled trial, 54 participants with fibromyalgia took 15 mg of saffron (ethanolic extract with 1.65-1.75 mg of crocin) or 30 mg of duloxetine daily for 1 week, then doubled the dose from 2 weeks until the end of 8.

Depression, fibromyalgia score (Fibromyalgia Impact Questionnaire), pain, fatigue, and anxiety were reduced comparably in both groups.

Adverse events weren't statistically significantly different.

The trial was preregistered IRCT201604261556N91