Saffron ( Crocus Sativus) Versus Duloxetine For Treatment Of Patients With Fibromyalgia: A Randomized Double-blind Clinical Trial
Notes for this study:
||Global Fatigue Index. Mean and SD. Duloxetine: before 41.51 (8.37), after 23.93 (8.36). Saffron: before 42.03 (8.62), after 25.13 (9.63).
|Number of Subjects
||18-29, 30-44, 45-64
In a randomized, double-blind, placebo-controlled trial, 54 participants with fibromyalgia took 15 mg of saffron (ethanolic extract with 1.65-1.75 mg of crocin) or 30 mg of duloxetine daily for 1 week, then doubled the dose from 2 weeks until the end of 8.
Depression, fibromyalgia score (Fibromyalgia Impact Questionnaire), pain, fatigue, and anxiety were reduced comparably in both groups.
Adverse events weren't statistically significantly different.
The trial was preregistered IRCT201604261556N91